Sheikh Mohammed bin Zayed touched down in Cairo on Tuesday, beginning his official visit to Egypt.
The Crown Prince of Abu Dhabi and Deputy Supreme Commander of the Armed Forces, was welcomed at Cairo International Airport by Egyptian President Abdel Fattah El Sisi.
The two held talks in the VIP lounge of the airport before moving to Etihadeya Palace in Cairo where Sheikh Mohammed said they discussed ways to strengthen and develop the two countries' relationship as well as regional and international issues.
"The UAE and Egypt are united by a long-standing historical relationship that is growing ever stronger," Sheikh Mohammed bin Zayed said in a statement on Twitter. "We stand together firmly against all attempts to interfere in the internal affairs of the Arab region or to undermine its security and stability."
The Crown Prince of Abu Dhabi said collaboration between the two countries is key to helping the region fend of risks particularly during the current era that is witnessing rapid changes and developments which require constant co-ordination among Arab countries.
Mr Sisi described the relations between the UAE and Egypt as a model of constructive co-operation, according to state news agency Wam
At the end of their meetings, both sides confirmed their keenness to develop the relationship between the two countries and highlighted the importance of strengthening stability in the region and confronting regional interference.
Sheikh Mohammed was accompanied by Sheikh Nahyan bin Zayed, Chairman of the Board of Trustees of Zayed bin Sultan Al Nahyan Charitable and Humanitarian Foundation, Dr Anwar Gargash, Minister of State for Foreign Affairs, Ali Al Shamsi, Deputy Secretary-General of the Supreme Council for National Security, Mohammed Al Mazrouei, Under-Secretary of the Crown Prince Court of Abu Dhabi, and Juma Al Junaibi, UAE Ambassador to Egypt.
Sheikh Mohammed last visited Egypt in April where he and Mr Sisi discussed how to enhance relations between the two countries as well as the overall regional and international issues of mutual interest.
Sheikh Mohammed bin Zayed meets Egyptian president El Sisi - in pictures
Sheikh Mohammed bin Zayed meets with Egypt president Sisi in Abu Dhabi