Mr El Sisi will meet Sheikh Mohamed bin Zayed, Crown Prince of Abu Dhabi and Deputy Supreme Commander of the Armed Forces, for the second time in six months.
The pair are due to discuss the "brotherly relationship" between the two countries and ways to strengthen co-operation, reported state news agency Wam.
Sheikh Mohamed followed up a visit to Cairo in August 2018 with trips to Egypt in March and May this year.
The regular engagements are a sign of the strong relationship between the two leaders.
This year, agreements in areas such as housing, irrigation, trade and industry have been signed between the countries, with further deals likely to be agreed to during this week’s visit.
This year, Sheikh Mohamed said the UAE considered “consolidating the brotherly relations with Egypt” to be a priority.
"The UAE's support for the Arab Republic of Egypt has been a mainstay of the country’s foreign policy since the late Sheikh Zayed bin Sultan Al Nahyan, who was aware of the pivotal role and historical and political leverage of Egypt, and was cognisant of the fact that Egypt's stability is fundamental to the security of all Arab nations," he said.
Mr El Sisi, a former general and Egyptian defence minister, was elected president in 2014.