New coach Mike D'Antoni saw his side lose again as Orlando came back from behind in the final quarter to win 113-103, while the New York Knicks shone in a 106-99 win over the Phoenix Suns.
NBA: Orlando Magic record comeback win against inconsistent Lakers
The Orlando Magic produced a superb final quarter to come from behind and defeat the LA Lakers 113-103.
Orlando were four points down heading into the final stanza but stepped up to the challenge as they outscored the Lakers 40-26 to claim victory.
Arron Afflalo top-scored with 30 points for Orlando, with Kobe Bryant topping him with 34 points in a losing cause.
"The way we lost the past three games, I'm sure our fans just wanted to see us win in general," Afflalo said afterwards.
"But for us to kick-start this road trip by playing well, against the Lakers in particular, they should be proud of that. It's a huge confidence boost for us."
The result means the Lakers have lost four of their seven games under new coach Mike D'Antoni, with another inconsistent performance featuring deficient defence.
"Seems like we can't get out of our own way," he said afterwards.
"I think our problem is just not coming out with the intensity and the purpose that we need to have. ... We're slow right now. Just athletically, we're struggling with young teams that run up and down."
The New York Knicks lit up Madison Square Garden with their third win in a row - a 106-99 success over the Phoenix Suns.
Carmelo Anthony led scoring with 34 points, while Raymond Felton was strong in support with 23 points, seven assists and no turnovers.
Marcin Gortat was the Suns' standout with for 18 points and 10 rebounds.
"I think they're a hell of basketball team. I really do," Alvin Gentry, the Phoenix coach, said after the game.
"When you add Iman Shumpert and Amar'e Stoudemire back to the mix, shoot, they're as good as anybody."