LeBron James hit 24 points as Miami closed to within seven wins of the 1971 Los Angeles Lakers' record winning run.
NBA: Denver's winning streak ended by New Orleans but Miami move to 27 in a row
Miami Heat moved within six wins of the Los Angeles Lakers' record after a 24-point effort from LeBron James secured a 108-94 win over Orlando Magic.
But Denver Nuggets' streak crashed to a halt after the New Orleans Hornets stung them 110-86.
First-place Miami are just six victories away from tying the Lakers, and haven't tasted defeat since February 1 on the road against the Indiana Pacers.
The dominant win over the Magic kicked off a four-game road trip for Miami, who have won 13 in a row as the visitors. On the upcoming road swing the Heat will also travel to Chicago, New Orleans and San Antonio, where they will face the mighty Spurs on Sunday. Wade is hoping to return for Wednesday's game against Chicago.
"We've been playing in a lot of competitive games over this streak so we're look forward to playing in Chicago against a very well-coached team," said James after their latest win.
"We will be ready for them."
James also had 11 assists and nine rebounds for the Heat, who were without Dwyane Wade for the second consecutive game.
Tobias Harris finished with a team-high 20 points for Orlando, but Miami They carried a 78-68 lead into the fourth and led by as much as 20 in the quarter.
Denver's trip to New Orleans ended in disappointment as their 15-game streak came to an abrupt end.
Ryan Anderson led the Hornets with 23 points, while Danilo Gallinari scored 24 for the Nuggets.
John Wall poured in 47 points to lift the Washington Wizards to a 107-94 victory over the Memphis Grizzlies.
Wall added eight assists to his career-high points haul, while Emeka Okafor contributed 21 points and nine rebounds.
Stephen Curry had 25 points and 10 rebounds as the Golden State Warriors saw off the Los Angeles Lakers 109-103, despite 36 points from Kobe Bryant.
Elsewhere, the Indiana Pacers beat the Atlanta Hawks 100-94 and the Utah Jazz were 107-91 winners over the Philadelphia 76ers.