Washington stunned the Giants with a comprehensive 14-2 win at AT&T Park, including a three-run double from Kurt Suzuki.
MLB round-up: Washington Nationals rout San Francisco Giants
The Washington Nationals were the night's big MLB winners, seeing off the San Francisco Giants 14-2 at AT&T Park.
Washington sent 12 men to the plate in a seven-run third inning which was capped by Kurt Suzuki's three-run double.
Although the hosts got off the mark in the seventh, there was no coming back as they were already trailing 14-0 at that stage.
The result means Washington has won 13 of its past 14 road games, and now has the best road winning percentage in the majors.
"The boys are in a good mood," Nationals manager Davey Johnson said.
"Just like the skipper. It was fun to watch the offence. We beat up on a pretty good pitcher."
San Diego Padres southpaw Eric Stults impressed, shutting down a potent Braves line-up to claim the series opener in Atlanta 4-1.
Cole Hamels became only the third Phillies pitcher in the past 20 years to throw consecutive shutouts and extended his scoreless-innings streak to 22 by hurling a seven-hitter against the Miami Marlins in a 4-0 Philadelphia success.
Adam Dunn hit his 397th and 398th career home runs, both solo shots, and Toronto's Moises Sierra launched his first Major League home run, but the game was not decided until David Cooper's single in the 11th inning gave the Blue Jays a 3-2 victory over the Chicago White Sox.
Nick Swisher reached the 200-homer plateau in style with a third-inning slam and Eric Chavez hit a leadoff homer in the sixth of the New York Yankees' 8-2 defeat of the Texas Rangers.
Recently-acquired outfielder Shane Victorino drove in three runs and hit his first homer for the LA Dodgers, who tightened the National League play-off picture with a 5-4 win over the Pittsburgh Pirates.
Chicago Cubs' Darwin Barney and Alfonso Soriano each belted a two-run blast off Houston Astros starter Armando Galarraga, making a winner of Jeff Samardzija - who tied a career high with 11 strikeouts in the 7-1 success in the series opener at Wrigley Field.
A four-run third inning set up the Tampa Bay Rays' 4-1 win at the Seattle Mariners, while the Cleveland Indians saw off the Los Angeles Angels 6-2.
Elsewhere, the Minnesota Twins sank the Detroit Tigers 9-3 and the Colorado Rockies saw off the Milwaukee Brewers 9-6.