Manchester United were given a helping hand by VAR in their 3-0 win at Aston Villa, while Tottenham suffered at the hands of technology during their 0-0 draw at Bournemouth.
Against Villa, United midfielder Bruno Fernandes spun into Ezri Konsa before tumbling in the area despite little evidence of a foul by the Villa defender.
The penalty stood after a VAR review and Fernandes scored his eighth goal since joining from Sporting Lisbon in January.
There was more VAR controversy at Dean Court, with Tottenham in danger of missing out on European competition for the first time since the 2009/10.
Jose Mourinho's team were left frustrated as Josh King's push on Harry Kane in the penalty area went unpunished despite a VAR review in the first half.
Also, the Premier League confirmed Southampton should not have had a penalty against Everton, the BBC reported.
James Ward-Prowse seemed to fall into the standing Andre Gomes, although he missed the penalty.
"It all changed on the penalty decision. Fernandes' first touch is on the ball, his second touch is on Konsa's shin," a frustrated Villa manager Dean Smith said.
"I can understand [referee] Jon [Moss] getting it wrong but if that goes to VAR I don't know what they are looking at. It's a disgraceful decision."
United boss Ole Gunnar Solskjaer disagreed: "I think it's a penalty. The boy sticks out his leg, Fernandes does a fantastic 'Zidane turn' and he lands on him."
Bournemouth v Tottenham ratings
A week after Tottenham were the victims of a VAR decision in their defeat at Sheffield United, Mourinho felt they were the victims of another bad mistake.
"The same referee who did the VAR decision against Sheffield United, Michael Oliver. Opinions matter, it's not only mine. Everybody knows that's a penalty and when I say everybody, I mean everybody," Mourinho said.
"Normally at minute five we would be winning 1-0 against a team in trouble, I think the game would be completely different.
"The game had the most important moment. You know when, you know who. Like Sheffield, the man of the match was not one of the players."