Germany's second tier became the first top professional European league to resume following the coronavirus lockdown on Saturday, ahead of the Bundesliga restarting later in the evening.
Four matches were underway behind closed doors and with strict health guidelines in place.
However, the game between Hanover and Dynamo Dresden was postponed after the Dresden squad was forced to quarantine for two weeks due to two positive tests for Covid-19.
South Korean Lee Jae-Sung scored the first Bundesliga goal in over two months by giving Holstein Kiel a third-minute lead at Regensburg.
The leagues are hoping to conclude by the end of June, having been suspended in mid-March, with nine rounds of regular-season matches to be played.
