In the relegation fight it will be a good weekend for Newcastle United and Swansea City.
Mohamed Salah inspires Liverpool to win at Man United, while Chelsea bounce back and Man City and Tottenham triumph: Premier League predictions
It is the last full round of Premier League games for three weeks, with the FA Cup quarter-finals and an international round of friendlies, between now and March 31.
Here is a look forward to what to watch for this weekend and how it can shape the top four and relegation fights.
Manchester United 1 Liverpool 2
Why? United showed great character to come from two down at Crystal Palace at Monday and win, but the result flatters a performance that for the large part was disappointing. Liverpool are a better side than Palace and with Mohamed Salah continuing to excel, Jurgen Klopp's men are well poised to exploit the fact that United are misfiring at present.
Everton 1 Brighton and Hove Albion 1
Why? Everton's home form is the key to the reason they are not more worried about their survival. Seven points from their past three games has left them seven points clear of the relegation zone. Brighton have shown impressive steel to have moved above Everton on goal difference, and Chris Hughton's side are worth a point here.
Huddersfield Town 1 Swansea City 2
Why? A number of clubs have changed managers during the season but Carlos Carvalhal has had the biggest impact. He has transformed Swansea from a side who were rock bottom to one now in 13th place having picked up 17 points from 10 games. Another three points can come here against relegation rivals Huddersfield.
Newcastle United 1 Southampton 0
Why? Both Newcastle, 16th in the table, and Southampton, 17th, have struggled for goals this season. But, in a tight encounter it is hard to look beyond Rafa Benitez's excellence at guiding sides with their backs against the wall, and with Dwight Gayle in good form they can take the points here.
West Bromwich Albion 1 Leicester City 2
Why? West Brom look like a doomed side already. They do not score enough and concede through silly mistakes at the other end. The omens are not good on a five-game losing streak ending here with Riyad Mahrez and Jamie Vardy leading Leicester's attacking threat.
West Ham United 0 Burnley 2
Why? It had been looking good for West Ham a month ago, but two defeats, the latter a thrashing at Swansea has left David Moyes's men back in trouble. Burnley won for the first time since December 12 last weekend at home to Everton, and they can grind out another win here with Ashley Barnes looking to net for the third successive games.
Chelsea 2 Crystal Palace 1
Why? This is an interesting one. Chelsea appear low in confidence after effectively waving the white flag at Manchester City, but then Palace let slip a two-goal lead to lose to Manchester United on Monday and have picked up just two points from their past six games. Chelsea have more quality ultimately and with Eden Hazard they should have too much for Palace.
Arsenal 2 Watford 0
Why? It has been an awful past month for Arsenal as they have lost three league games and the League Cup final. Confidence is low, but Arsene Wenger's men can finally end their misery against a Watford side who have not won away since November 25. Pierre-Emerick Aubameyang was their lone bright spot at Brighton last weekend and he can be again here.
Bournemouth 0 Tottenham Hotspur 3
Why? Tottenham will look to bounce back from their disappointing loss to Juventus and they can do so at Bournemouth, who have only kept two clean sheets at home this season. Heung-Min Son is on great form for Spurs with five goals in his past three games.
Stoke City 0 Manchester City 4
Why? City do not play again until March 31 after this, with a warm weather training trip to Abu Dhabi ahead next week. They should get on the plane on Tuesday even closer to winning the title as the line-up of Sergio Aguero, Gabriel Jesus and Kevin de Bruyne should be far too good for struggling Stoke.