The good news for the sides in European action in the Premier League is that they do not have to worry about about those competitions until February now that the group stages are over.
Liverpool can look to cap a great past week that has seen them go back top of the Premier League as well as reach the last 16 of the Uefa Champions League.
They host Jose Mourinho's Manchester United and another setback on Sunday at 8pm UAE time for the Portuguese manager could leave him under even more pressure.
Nearest challengers Manchester City will look to get their title tilt going again with a home win against Everton on Saturday at 4.30pm, while at the other end of the table bottom side Fulham have a London derby with West Ham United.
Ahead of this round of fixtures, sports editor Graham Caygill has made his predictions and explained his reasoning in the photo gallery above. To move on to the next photo, click on the arrows, or if using a mobile device, simply swipe.