A look at all eight ties making up the last 16 of the competition ahead of the weekend's action.
Chelsea, Tottenham and Man City progress as Mourinho's Man United held by Huddersfield: FA Cup predictions
We are down to the last 16 teams in the FA Cup as the Premier League takes a weekend off from action. Here is what to expect from the games, spread over four days, with expectations being it will be eight top flight sides who make it through to the quarter-finals.
Leicester City 2 Sheffield United 1
Why? Leicester's league form has been inconsistent of late but with the goal threat of Jamie Vardy they should have too much quality for Championship side Sheffield United. Claude Puel's side can look to the cup as a welcome distraction from the Riyad Mahrez affair, with the club hoping the Algerian can move on after his disappointment at failing to secure a move to Manchester City in January.
Chelsea 3 Hull City 0
Why? The FA Cup is probably Antonio Conte and Chelsea's best chance of silverware with their hopes of retaining the Premier League long gone. With Barcelona coming up in the Uefa Champions League next week it will be interesting to see what side he fields, but it will be a surprise if Eden Hazard does not feature and inspire the London side to the quarter-finals.
Sheffield Wednesday 1 Swansea City 3
Why? Interesting match-up this as Carlos Carvalhal takes his revitalised Premier League to his former club Sheffield Wednesday. Swansea are on terrific form at present with 14 points from their past eight games and they will carry that through to defeat their Championship opponents.
Brighton and Hove Albion 2 Coventry City 0
Why? Coventry's run to the last 16 has been one of the stories of the FA Cup this season as the 1987 winners, now in League Two, have produced a number of upsets. Brighton will be a bridge too far for them though. Chris Hughton's side are well organised and tough to break down and they will be too good for their lower league opponents.
West Bromwich Albion 1 Southampton 2
Why? Southampton won at West Brom two weeks ago in the league and while both sides are in the relegation zone, it is clearly Southampton who have the more upside and momentum. Mauricio Pellegrino's side to prevail and give themselves a confidence boost ahead of an important run of games in the Premier League.
Huddersfield Town 1 Manchester United 1
Why? Huddersfield beat United at home in October and have regained some belief after thrashing Bournemouth last weekend. United have yet to click with Alexis Sanchez in the side as Jose Mourinho looks for the optimal formation and this could well be an occasion where the Portuguese manager is content to take the tie back to Old Trafford.
Rochdale 0 Tottenham Hotspur 3
Why? Rochdale's boggy pitch has been the main talking point ahead of this match. Tottenham had a scare in the last round against Newport County and they are unlikely to do that again, with Harry Kane and Dele Alli looking as if they are getting back to their best form.
Wigan Athletic 1 Manchester City 4
Why? The last two times these two sides have met in the FA Cup it was Wigan who came out on top surprisingly. But do not expect a hat-trick as Pep Guardiola's men stay on track in their bid to win the quadruple with so many of their top players such as Sergio Aguero, Kevin de Bruyne and Raheem Sterling firing on all cylinders at present.