Harry Kane will be sidelined until April after Tottenham Hotspur revealed the England captain needs surgery to repair a ruptured tendon in his left hamstring.
Kane suffered the injury while taking a shot during Spurs' Premier League defeat at Southampton on New Year's Day, with specialists recommending that an operation was needed.
The 26-year-old has scored 27 goals in 31 appearances for club and country this season.
The news presented another headache for Spurs manager Jose Mourinho, who has also seen midfielder Moussa Sissoko sidelined until April after undergoing knee surgery.
Spurs also have first-choice goalkeeper Hugo Lloris recovering from injury, along with summer signing Tanguy Ndombele as well as full-back pairing Danny Rose and Ben Davies.
Kane will now also miss England's friendlies against Italy and Denmark at the end of March.
However, if all goes well in his rehabilitation, Kane should be back in good time to lead the Three Lions into Euro 2020.
After the Southampton defeat, Mourinho said: "Everybody knows who he is, what he is, what he means for the team, the fans, the club.
"His quality, the routines that the team has playing with him, every minute of every game he doesn't play we miss, so every match that he doesn't play we're going to miss him."