In the first Uefa Champions League match hosted in Barcelona since the independence referendum, Ernesto Valverde's side will host one of his former clubs.
Barcelona v Olympiakos: Camp Nou reopens after empty stadium protest during Catalan tensions
For the first time since playing to an empty stadium in protest at a violent crackdown of an independence referendum in Catalonia, Barcelona's Camp Nou opens its doors when Olympiakos visit on Wednesday.
On the field, Barca should have little problem sweeping aside an Olympiakos side without a point in the Uefa Champions League so far this season to consolidate their position atop Group D.
However, how Barca's fans will react to a tumultuous few weeks of political tension in Catalonia is less predictable with the support split like the rest of society on wealthy northeastern region of Spain.
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Chants in favour of independence are common at the Camp Nou from a section of the Barca fanbase, most notably in the 17th minute to mark the fall of Catalonia in the Spanish War of Succession in 1714.
Barca have also been repeatedly fined by Uefa for fans flying the Catalan 'Estelada' flag, which has become a symbol of the independence movement within Catalonia, at Champions League matches.
Leading Barca players such as Gerard Pique and Andres Iniesta called for politicians on both sides of the independence debate to negotiate in the wake of the October 1 referendum.
As Spanish riot police fired rubber bullets and seized ballot papers leaving 92 injured, among nearly 900 who sought medical attention that day, Barca beat Las Palmas 3-0 behind closed doors.
Club president Josep Maria Bartomeu insisted he tried to have the match abandoned, but instead settled for showing their opposition by playing the match in an empty 99,000 capacity Camp Nou.
Yet, players have been less keen to position themselves on the confused political fallout in the past few weeks.
A standoff has ensued with Spanish Prime Minister Mariano Rajoy calling on Catalan leader Carles Puigdemont to clarify if he has declared independence for Catalonia on the basis of the referendum, deemed illegal by the Spanish government.
"What we like is playing and enjoying ourselves in a spectacular atmosphere like today," said Iniesta after Barca's 1-1 draw at Atletico Madrid on Saturday.
Barca's first visit to the capital since the escalation of the political divide was expected to provoke a hostile welcome for the visitors. However, other than the waving of more Spanish flags than normal at Atletico matches and some jeers for Pique, the match passed off peacefully.
"It was a great game, in a great atmosphere, in a great stadium," said Barca manager Ernesto Valverde.
Despite a series of distractions on and off the field, including the loss of Neymar to Paris Saint-Germain and calls for Bartomeu to resign on top of the Catalonia crisis, Barca have started impressively under Valverde.
A run of nine straight wins in the Primera Liga and Champions League was ended on Saturday, but Barca are heavy favourites to get back to winning ways against one of Valverde's former clubs.