Dwight Howard had 23 points and 15 rebounds despite a horrific 7-for-19 performance at the free-throw line for the Lakers, while Kobe Bryant scored six of his 25 points in the final two minutes.
Although 61-year-old D'Antoni is still unsteady on his surgically replaced knee, he coached Los Angeles to a narrow victory that snapped Brooklyn's five-game winning streak.
Brook Lopez scored 23 points and Deron Williams had 22 for the Nets, who missed five of their last six shots in their ninth consecutive loss to the Lakers.
Raymond Felton and JR Smith had 15 points apiece for the Knicks, who improved their own record to an NBA-best 8-1 while inflicting a fourth straight defeat on the Hornets.
With rookie Anthony Davis ruled out through injury, Ryan Anderson scored 15 points to lead the Hornets offence.
Jason Richardson scored 21 points while Jrue Holiday, who put the 76ers ahead for the first time with a three-pointer just before half-time, had 19 points and 12 assists.
DeMar DeRozan led the Raptors with 24 points, while Andrea Bargnani had 22.
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