Victoire Pisa, the Dubai World Cup winner, will not defend his crown at Meydan racecourse in March and has been retired.
The four year old, who was the first Japanese runner to win the world's richest race, will stand at Shadai Farm in Japan following a catalogue of injuries.
"I feel I should apologise to him because I couldn't get him back to his best, but at least I am happy that I can send him to the stud without any further accidents," Katsuhiko Sumii, the trainer, told the Racing Post.
"He was the leader of my stable after Vodka's retirement, and I wish him all the best in his future as a stallion - he is a world-class Grade 1 title holder."
Victoire Pisa won almost Dh44.7 million during a career that also included wins in the Japanese 2,000 Guineas as well as third place in the Japanese Derby. The victory at Meydan in March was particularly poignant as Victoire Pisa lead home compatriot Transcend and their one-two occurred just 15 days after the devastating tsunami and earthquake that swept through Japan.
The son of Neo Universe was an intended runner in the Audemars Piguet Queen Elizabeth II Cup at Sha Tin in May but was discovered to be lame in his right-hind leg.
An attempt to improve on last year's seventh place in October's Prix de l'Arc de Triomphe also resulted in a leg injury after a workout in August, just days after arriving in France. Victoire Pisa finished 13th in the Japan Cup last month despite Sumii claiming his horse was "at his peak".
On Sunday, the colt finished eighth out of 13 in the Arima Kinen, arguably Japan's most coveted race won, by Orfevre.