Fulham 3 // Blackpool 0
Zamora, making his first league start in seven months since breaking his leg, scored twice in five minutes in the middle of the first half in a victory that lifted Fulham to 10th and left Blackpool in 17th, one point above the drop zone.
His opener was a sizzling right-footed shot into the roof of the net and his second a glancing header after a pinpoint free kick from Danny Murphy from the right.
Fulham, who have not lost at home in the league this year, dominated throughout and added a third in the 72nd minute when Dickson Etuhu tapped in a square ball from Brede Hangeland after Clint Dempsey had hit the post with a header.
Blackpool's best chance came just before half-time when Brett Ormerod headed past the onrushing keeper Mark Schwarzer but he was denied as Chris Baird headed off the line, while James Beattie also hit the post for the Seasiders.