With captain Michael Clarke showing the way at Old Trafford on Sunday, Australia recorded their highest one-day international total against England – in England – to win by 88 runs and take a 1-0 lead in the three-match series.
Clarke's 105 was his eighth ODI century and helped steer Australia to 315 for seven.
England lost early wickets in their pursuit of what would have been a record chase and never recovered to be bowled out for 227 from 44.2 overs.
Man-of-the-match Clarke was pleased to claim a win following the 3-0 Ashes Test series defeat.
"It's a nice feeling. The boys deserve credit as to make more than 300 on that wicket was a really good score and our bowlers executed well," he said.
"It doesn't matter how you win it's about crossing the line. As a one-day outfit that's our goal. We are here to win the series and 1-0 is a good start.
"I always want more runs and hopefully this is the start of a few more during the series."
England's ODI captain Eoin Morgan was keen to put the match behind him.
"Not to get a win under our belt is disappointing but we can learn a lot from today. Moving on from here we are looking forward to Wednesday," he said.
"We have a very strong batting line-up and one we have confidence in regardless of whether we bat or bowl first .
"We have a lot of bowling options and guys we can turn to. [Batting wise] there were not enough guys putting their hands up.
"We felt the lengths we tried to hit at the back end and middle period where Australia played really well and we just didn't cope well with the wicket.
"Unfortunately today we lost wickets at unfortunate times.
"We struggled to cope with the conditions and 300-plus was a big ask for us."
Australia's score, on a tricky surface, was built around a 155-run stand, from 133 balls, between Clarke and George Bailey (82) for the fourth wicket. "Winning is a habit," Bailey said. "So we will take any win we can at the moment."
Clarke became the first Australian to score an ODI century, from 94 balls, at Old Trafford before he was caught behind off Boyd Rankin (2-49).
England, who had put Australia in on a pitch of slightly uneven pace, needed to pull off their highest successful chase in this format.
Despite half-centuries from Kevin Pietersen (60), Morgan (54) and Jos Buttler (75), they never seriously threatened the Australian total. From nine for two, there already appeared to be no way back – and so it proved as England were eventually bowled out with the final 5.4 overs unused.
Clint McKay (three for 47) – with support from Mitchell Johnson (two for 36) who took those two crucial early wickets – was the pick of the Australia bowlers and completed his side's win when Steven Finn picked out Adam Voges at deep midwicket.
Australia lead the five-match series 1-0 after Friday's opener at Headingley was washed out without a ball being bowled.
The third match is at Edgbaston in Birmingham on Wednesday.
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